Abstract #2353

Functional connectivity underlying attentional deficits in children born preterm

Trevor McComber Flynn¹, Olga Tymofiyeva¹, Dawn Gano², Donna M Ferriero³, A James Barkovich⁴, and Duan Xu¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Neurology, University of California San Francisco, San Francisco, CA, United States, ³Pediatrics, University of California San Francisco, San Francisco, CA, United States, ⁴Radiology, University of California San Francisco, San Francisco, CA, United States

Children born very preterm are at a increased risk to develop attention deficits. Here we employ fMRI connectivity analysis to study the functional connectivity underlying these attention deficits in preterm children ages 10-14. Subjects were separated into normal and attention deficit groups and then group differences in voxelwise connectivity from 16 seed regions were delineated using AFNI. Significant clusters of hypoconnectivity in the attention deficit group were found in eight of the ROIs, primarily from the middle frontal gyri and anterior cingulate cortices, as well as hyperconnectivity from the right anterior insula.

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