Functional and structural neuroimaging studies have revealed abnormal of Primary Insomnia (PI) patient's brain, including decreased gray matter density, and increase of spontaneous brain activity and metabolism in hippocampus and fronto-parietal cortex, and so on. We use graph-based approaches to investigate the topological abnormalities of functional brain networks in PI patients and examine clinical correlates of the alterations. PI patients exhibited increased overall connectivity of functional brain networks and nodal efficiency in the default mode network (DMN) and emotional circuit. This abnormal organization of large-scale functional brain networks in PI, which could account for memory and emotion dysfunction in PI patients.
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