In the absence of detectable epileptiform activity, even combined EEG-fMRI scanning may fail to detect the epileptic foci. We utilize a novel measure of BOLD signal stability, the coefficient of variance (CV), with ultra-fast fMRI sequence MREG in drug resistant epilepsy (DRE). We detect a robust increase of MREG CV in patients with in white matter, brainstem and cerebellum in DRE at group level. Importantly, thresholding the CV +3 std above mean enables individual level mapping of epileptic abnormality in DRE patients.
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