In our previous work using preclinical 7T MRI scanner we have shown that tumors in mice can be imaged using CEST-MRI of glucosamine. Moving toward clinical application, considering the excellent safety profile of glucosamine, we tested the CEST-MRI of glucosamine on a 3T clinical scanner. Here we report significant CEST MRI signal up to ~3.5 ppm from the water signal corresponding to the exchangeable protons of the glucosamine hydroxyls and amine residues. Thus, CEST MRI using glucosamine has the potential to report on the activity of tumor metabolism, noninvasively by using MRI.
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