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Abstract #2244

Presaturation power adjusted pulsed (PPAP)-CEST: A method to increase the independence of target CEST signals

Kazufumi Kikuchi1, Keisuke Ishimatsu1, Shanrong Zhang1, Ivan E. Dimitrov1,2, Hiroshi Honda3, A. Dean Sherry1, and Masaya Takahashi1

1Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Philips Healthcare, Gainesville, FL, United States, 3Kyushu University, Fukuoka, Japan

We previously demonstrated in the phantoms that the chemical exchange saturation transfer (CEST) peaks identified during 0 to 3.5 ppm are often quite broad and overlap with each other, which caused in obvious interference between the CEST signals. We attempted a presaturation power adjusted pulsed (PPAP)-CEST method which aimed to increase the independence of glutamate CEST signal by eliminating an interference from a neighboring CEST signal in the kidney in mice. The CEST signal of glutamate was less impacted by concentration changes in other exchanging species by subtracting CEST signals at two different power levels.

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