We present a 3D CEST sequence that allows 2mm isotropic whole-brain acquisition within 6s per frequency offset. The 4.5s CEST preparation is followed by a 1.5s centric-reordered 3D-EPI readout with water excitation. The single-shot readout improves robustness against physiological noise and provides complete freedom in the design of the saturation block. We acquired whole-brain CEST data at 7T and show metabolite maps obtained from a Lorentzian fit to the Z-spectra.
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