Selective inversion recovery quantitative magnetization transfer (SIR-qMT) imaging offers increased efficiency relative to conventional pulsed-saturation qMT due to its ability to quantify MT parameters without the need for independent estimates of B0, B1+, and T1. Despite this, qMT acquisition at a reasonable resolution over a large field of view remains prohibitively time consuming. Here, we employ an optimised acquisition strategy and accelerated readouts to acquire whole-brain SIR-qMT data at 2 x 2 x 3 mm3 resolution in ~10 minutes; opening the door to qMT imaging on a time scale practical for clinical application.
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