Abstract #2207

Applications of magnetic susceptibility source separation: multiple sclerosis lesions and line of Gennari

Jingu Lee¹, Taehyun Hwang¹, Yoonho Nam², Jinhee Jang², Woojun Kim³, Se-Hong Oh⁴, Masaki Fukunaga⁵, and Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, ²Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, ³Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, ⁴Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Republic of Korea, ⁵Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Japan

Magnetic susceptibility source separation is a recently proposed technique that generates positive and negative susceptibility maps corresponding to iron and myelin distributions in the brain. In this study, iron accumulation and myelin degradation in a few typical types of multiple sclerosis lesions were visualized using the magnetic susceptibility source separation method. Additionally, the well-known co-localization of iron and myelin in the Gennari line was demonstrated in an ex-vivo brain sample.

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