Abstract #2203

Nonlinear projection onto dipole fields with preconditioning (nPDF)

Carlos Milovic^1,2, Berkin Bilgic³, Bo Zhao³, Christian Langkammer⁴, Julio Acosta-Cabronero⁵, and Cristian Tejos^1,2

¹Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, ²Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile, ³Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, ⁴Department of Neurology, Medical University of Graz, Graz, Austria, ⁵Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom

QSM requires to remove fields originated outside a region of interest prior to inversion. This is prone to generating artifacts due to noise and error propagation from previous processing steps such as coil combination or phase unwrapping. To address this, we reformulated the widely used projection onto dipole fields (PDF) method as a nonlinear problem with pre-conditioning. This new formalism is wrap-insensitive, results in improved noise/error management, and might enable a more straightforward implementation of multi-coil/-echo combination and background removal steps into a single optimizer.

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