Abstract #2195

Simultaneous quantification of fat fraction, susceptibility and R2* from a single GRE acquisition: flip-angle effects

Junmin Liu¹, Spencer Christiansen^1,2, and Maria Drangova^1,2

¹Imaging Research Laboratories, Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada, ²Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada

We report on a systematic investigation of the flip-angle (FA) effects on the quantification of fat fraction (FF), susceptibility, and R2* simultaneously from a single multi-echo GRE (mGRE) acquisition. Using a phantom with a range of oil-water emulsions and aqueous Gadolinium solutions we tested five different FAs (1°, 3°, 5°, 8° and 15°) with a bipolar mGRE protocol and were able to successfully generate the FF, susceptibility and R2* maps for all cases. Our results demonstrate that a single mGRE scan with optimized TEs has the potential to accurately measure quantitative FF, susceptibility, and R2* with a FA of 8°.

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