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Abstract #2157

Quantitative T1-difference maps and T1-weighted difference images: which modality is better at identifying tumor infiltration in high grade gliomas?

Ulrike Nöth1, Ralf Deichmann1, Oliver Bähr2, Julia Tichy2, Stephanie Lescher3, and Elke Hattingen4

1Brain Imaging Center (BIC), Goethe University, Frankfurt/Main, Germany, 2Dr Senckenberg Institute of Neurooncology, Goethe University, Frankfurt/Main, Germany, 3Institute of Neuroradiology, Goethe University, Frankfurt/Main, Germany, 4Funktionseinheit Neuroradiologie, Radiologische Klinik der UKB, Bonn, Germany

In glioblastoma patients, differences of quantitative T1 (qT1) maps acquired before and after contrast agent (CA) administration are visually compared to the respective differences of conventional T1-weighted (T1w) images. Quantitative T1-differences are determined in the following regions-of-interest (ROIs): (1) enhancing tumor, (2) edema, (3) 5mm-rim around (1)+(2), (4) control tissue contralateral to the tumor. T1w- and qT1-differences clearly show the enhancing tumor, but only the qT1-difference maps show signal enhancement in the edema, which is in line with elevated qT1-difference values in this ROI. This indicates most likely CA leakage due to tumor infiltration.

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