Abstract #2140

Robust Quantification of Changes in Arterial Cerebral Vasculature Post Radiation Therapy in Pediatric Brain Tumor Survivors

Sivakami Avadiappan¹, Sam Payabvash¹, Angela Jakary¹, Erin Felton², Melanie Morrison¹, Christopher P Hess^1,2, Sabine Mueller^2,3, and Janine M Lupo¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Neurology, University of California, San Francisco, San Francisco, CA, United States, ³Department of Neurological Surgery, University of California, San Francisco, San Franciso, CA, United States

With the improved long-term survival of children with brain tumors, understanding the late effects of their therapy on small arterioles is of great importance. We developed a method for robust segmentation of arteries and quantification of their thickness using TOF-MRA at 7T and estimated the vessel radii distribution in irradiated patients compared to controls. Radiation-induced damage to the microvasculature resulted in a higher fraction of small vessels observed with time from radiation therapy, likely due to vessel thinning.

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