Using contrast agent in fMRI has the benefits of providing additional information of regional cerebral blood volume (CBV) and of enhancing sensitivity. Response comparisons of BOLD and MION enhanced CBV fMRI to the noxious stimulus in non-human primate showed signal increase for MION fMRI in the regions that are important in pain-processing network. Activities of some brain areas, including putamen, were captured with MION fMRI, not with BOLD. Capsaicin treatment augmented the responses of fMRI to the noxious stimulation for BOLD and MION fMRI. New insight can be obtained for the pain network through the comparison between BOLD and CBV fMRI.
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