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Abstract #2112

Physical exercise enhances adult cortical plasticity in neonatal hypoxic ischemic injured rats: Evidence by BOLD-fMRI and LFP electrophysiological recording

Sun Young Chae1,2, Jun Ho Jang3, Geun Ho Im4,5, Moon-sun Jang4,5, Won-Beom Jung2,6, Seungsoo Chung7, and Jung Hee Lee1,2,4,6

1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan university, Seoul, Republic of Korea, 2Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea, 3BnH Research co.,Ltd, Goyang, Republic of Korea, 4Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 5Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul, Republic of Korea, 6Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 7Department of Physiology, Yonsei University Colleage of Medicine, Seoul, Republic of Korea

The developing brain has a powerful ability to modify its own structure and function for recovery from injury in efforts to compensate for loss of function1,2. In critical period, developing brain has maximal neuronal synaptic connections so it is most amenable to changes in response to external stimulus such as physical exercise3. However, after critical period, neuronal synaptic connections are reduced, and maintained at the reduced state3. Here, we demonstrate enhanced neuroplasticity with physical exercise performed beyond critical period for rats that are injured during critical period. We obtained the BOLD-fMRI response and the interneuron activity with LFP electrophysiological recording.

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