The consequences of severe deficiencies in micronutrients especially vitamin B12 on the developing brain during infancy and early post-natal period is not very clear. The current study aim to understand the effects of B12 deficiency on cognitive function using 1H-[13C]-NMR spectroscopy together with [1,6-13C2]glucose infusion in vitamin B12 deficient mice. Our findings indicate reduction in the metabolic activity of glutamatergic and GABAergic neurons in the prefrontal cortex of mice maintained with moderate and severe vitamin B12 defcient diet.
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