Abstract #2070

Cerebral Vascular Reactivity and Cognitive Decline in Healthy and in Early Stages of Pathological Aging.

Naila Boudiaf¹, Jan Warnking², Olivier Moreaud³, Johan Pietras⁴, Eric Condamine², Nathalie Fournet⁵, Amandine Bossant⁶, Monica Baciu⁷, and Alexandre Krainik¹

¹Neuroradiology, CHU Grenoble, Grenoble, France, ²Grenoble Institute of Neuroscience, Grenoble, France, ³Neurology, CMRR Grenoble, CHU Grenoble, Grenoble, France, ⁴IRMAGE, Grenoble, France, ⁵CNRS, LPNC, Chambéry, France, ⁶CHU Grenoble, Grenoble, France, ⁷CNRS, LPNC, Grenoble, France

Cerebral blood flow (CBF) and cerebral vascular reactivity (CVR) decrease with age and might affect cognitive functions. In this study, we investigated their correlation with cognitive abilities during normal and pathological aging.

We performed neuropsychological assessments on thirty-four participants: 13 healthy-young, 10 healthy-old and 11 impaired-old. We measured CBF and CVR using hypercapnia and Arterial Spin Labeling imaging.

Regarding the impaired-old, we found specific decrease in executive functions, short-term and working memory. Significant correlations were found between CVR and cognitive scores. Global CBF correlated only with age.

Unlike CBF, CVR reduction was specifically associated with cognitive decline during aging.

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