There is an increasing body of evidence that suggests vascular dysfunction may play an important role in Alzheimer’s Disease (AD)1. Hyperperfusion has been shown to be associated with mild cognitive impairment (MCI) and hypoperfusion with the onset of AD, along with neurodegeneration2,3. In this study we utilized a novel imaging modality, QUTE-CE MRI4,5, to study the micro- and macro- vascular abnormalities in a APOE-ε4 knock-in model, since the APOE-ε4 allele is the single most important genetic risk factor for AD. While our 173-region characterization reveals both hyper- and hyop-vascularization, the changes in microvascularity are almost entirely hypervascular.
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