Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized pathologically by amyloid beta (Aβ) deposition, microgliosis, and iron dyshomeostasis. The goal of this work was to observe how brain iron levels temporally influence Aβ plaque formation, plaque iron concentration, and microgliosis. Humanized APPNL-G-F knock-in and control mice were fed either lipophilic iron compound 3,5,5-trimethylhexanoyl ferrocene (TMHF), normal, or iron deficient diets for twelve months. Increased brain iron was observed in the olfactory, frontal and hippocampal regions and was associated with increased plaque-iron loading and microglial iron inclusions.
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