Abstract #1995

Quantitative T1 and T2 mapping with standard and MR fingerprinting techniques to assess frontotemporal dementia: A pilot study

Stilyana Peteva Bakoeva¹, Vera Catharina Keil¹, Alina Jurcoane¹, Mariya Doneva², Thomas Amthor², Peter Koken², Burkhard Mädler³, Wolfgang Block¹, Klaus Fließbach⁴, and Elke Hattingen¹

¹Department of Radiology, University Hospital Bonn, Bonn, Germany, ²Philips Research, Hamburg, Germany, ³Philips Healthcare, Bonn, Germany, ⁴Department of Psychiatry, University Hospital Bonn, Bonn, Germany

This pilot study explored the utility of MR fingerprinting (MRF) and standard T1 and T2 relaxometry to discover focal anomalies in patients with the primary progressive aphasic form of frontotemporal dementia (FTD). MRF and standard techniques revealed longer T1 and T2 relaxation times of cortex and deep white matter as well as the hippocampus (left>right) in FTD compared to healthy controls. Relaxation times between MRF and standard differed and not all techniques revealed all structures as altered in relaxation time. In conclusion, MRF and standard relaxometry have the potential to quantify brain anomalies in FTD, which may be used for diagnosis and monitoring, but are not interchangeable.

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