Abstract #1977

Comparison of Two Methods for the Measurement of T1 Hyperintensity in Multiple Sclerosis Patients with Repeated Exposure to Gadolinium-Based Contrast Agents

Megan Hii¹, Heejun Kang^1,2, Megan Le¹, Andrew Riddehough¹, Anthony Traboulsee¹, Shannon Kolind¹, David Li^1,2, and Roger Tam^1,2

¹MS/MRI Research Group, Division of Neurology, University of British Columbia, Vancouver, BC, Canada, ²Dept of Radiology, University of British Columbia, Vancouver, BC, Canada

Exposure to gadolinium-based contrast agents is associated with long-term increase in T₁ signal intensity in deep grey brain structures, but the measurement methodologies have not been well investigated. We propose marking regions of interest (ROIs) on registered serial T₂w images, and compared two methods for measuring the signal changes in the corresponding T₁w images: 1) Align the T₁w to the T₂w images (T₂-space), and 2) Map the ROIs marked on the T₂w images to the T₁w images (T₁-space). Applying these methods to frequent and infrequent scanning cohorts, we found signal increase to be associated with GBCA exposure, and T₁-space is more sensitive.

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