This study describes co-registered rsfMRI and MRSI data in poorly localized epilepsy patients with the goal of identifying the aberrant epilepsy network. We used 3T rosette encoded spectroscopic image covering the fronto-parietal-temporal brain regions in conjunction with resting fMRI data. The MRSI defined masks of metabolic dysfunction which was then forward warped using Bo maps to define the equivalent regions in the rsfMRI data. The rsfMRI data was analyzed with a model-free evaluation of local connectivity (regional homogeneity). Regions identified by MRSI as metabolically abnormal exhibited lower local rsfMRI coherence in comparison to gray matter or temporal regions.
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