Deep brain stimulation (DBS) of both the subthalamic nucleus (STN) and globus pallidus interna (GPi) are well-recognized effective treatments for Parkinson’s disease (PD). The mechanism of DBS and network responses produced by stimulation of these targets remains unknown. Conditional labeling of DBS now allows fMRI to be performed in the ON state. We examine whether GPI DBS and STN DBS affect blood oxygen level dependent (BOLD) brain activation/deactivation patterns similarly. Results show that both types of DBS activate the thalamus and deactivate the primary motor cortex; while the STN cohort showed activation in the cerebellum, an opposite effect was apparent in the GPi cohort.
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