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Abstract #1941

QSM versus R2* to study iron deposition in the substantia nigra and subthalamic nucleus in Parkinson’s disease and REM sleep behavior disorders

Mathieu David Santin1,2, Nadya Pyatigorskaya1,2, Romain Valabregue1,2, Rahul Gaurav1,2, Lydia Yahia Cherif1,2, Sara Fernandez-Vidal1,2, Eric Bardinet1,2, Graziella Mangone2, Isabelle Arnulf2, Marie Vidailhet2, Jean-Christophe Corvol2, and Stéphane Lehéricy1,2

1CENIR, ICM, Paris, France, 2Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France

Here, we compared R2* relaxation rate and QSM to study iron deposition in the substantia nigra (SN) and subthalamic nucleus (STN) in patients with early PD and idiopathic REM sleep behavior disorders with two different segmentation methods. PD patients showed increased iron deposition in the SN and STN as compared with healthy controls with QSM and R2*. iRBD only showed an increase tendency of QSM values compared to healthy controls. Obtained p-values were more systematically lower in QSM than in R2*.

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Abstract