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Abstract #1865

Pathological differentiation of multiple sclerosis lesions based on R2* at 3T: The influence of iron and myelin

Christoph Birkl1,2, Vanessa Wiggermann1,3,4, Verena Endmayr5, Enedino Hernandez-Torres1,4, Gregor Kasprian6, Romana Hoeftberger7, Stefan Ropele2, Simon Hametner5,8, and Alexander Rauscher1,3,4,9

1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 4Department of Pediatrics (Devision of Neurology), University of British Columbia, Vancouver, BC, Canada, 5Center for Brain Research, Medical University of Vienna, Vienna, Austria, 6Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 7Institute of Neurology, Medical University of Vienna, Vienna, Austria, 8Institute of Neuropahtology, University Medical Center Goettingen, Goettingen, Germany, 9Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada

Magnetic-susceptibility sensitive MRI as measure for tissue damage in multiple sclerosis (MS) lesions has been controversial, since the relationship between the MR signal and the underlying pathology is not fully understood. Here we assessed R2* of different white matter MS lesion types and normal appearing white matter (NAWM) in relation to the underlying iron and myelin densities. We observed lower R2* in all MS lesion types compared to NAWM, driven by lower iron and myelin densities. Shadow plaques showed significant higher R2* values than other MS lesions, in line with the hypothesis of remyelination and supported by myelin histology.

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