Abstract #1863

Quantitative MRI of diffusely abnormal white matter in multiple sclerosis at 3T

Irene M Vavasour¹, Roger Tam^1,2, Shannon H Kolind^1,2,3,4,5, Robert L Carruthers³, Anthony Traboulsee^2,3, David KB Li^1,2,3, and Cornelia Laule^1,4,5,6

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²MS/MRI Research Group, University of British Columbia, Vancouver, BC, Canada, ³Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ⁴Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁵International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, ⁶Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Diffusely abnormal white matter (DAWM) is found in the brain of some multiple sclerosis (MS) and clinically isolated syndrome (CIS) subjects. DAWM has poorly defined boundaries, with signal intensity higher than normal appearing white matter (NAWM) but not as high as lesions on FLAIR, proton density and T₂-weighted MRI. We compared results from myelin water imaging, T₁ and diffusion basis spectrum imaging in areas of DAWM and corresponding areas of NAWM in 20 MS/CIS participants. No significant differences in measures sensitive to myelin, axons, oedema and inflammation were found, although trends for increased T₁ and reduced fibre fraction were observed.

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