Abstract #1854

Multicomponent relaxation analysis of myelin in the brains of rare progressive solitary sclerosis, compared to multiple sclerosis and healthy control subjects in vivo

Lisa Eunyoung Lee¹, Jillian Chan¹, Irene Vavasour², Roger Tam², Anthony Traboulsee¹, Robert Carruthers¹, and Shannon Kolind^1,2

¹Department of Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ²Department of Radiology, University of British Columbia, Vancouver, BC, Canada

Progressive solitary sclerosis (PSS) presents with an isolated demyelinating lesion along the corticospinal tract that results in progressive motor deficits. We used mcDESPOT-derived parameters to better understand the pathology in the normal-appearing white matter tracts (WMT) of PSS compared to relapsing-remitting multiple sclerosis (RRMS) and healthy control (HC) subjects. Overall, we found a trend of lower MWF (myelin content) and higher qT₁ (inflammation/edema) in WMT in PSS, compared to RRMS and HC subjects. This suggested that there might be more extensive myelin damage in the normal-appearing brain, beyond the lesional site, that may be driving disease progression in PSS.

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