Abstract #1846

The Observable Fraction of Myelin Lipid 1H Magnetization Imaged by IR-ZTE

Alan C Seifert^1,2, Michael J Wilhelm³, Suzanne L Wehrli⁴, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Chemistry, Temple University, Philadelphia, PA, United States, ⁴SAIF Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Direct detection of myelin using solid-state imaging methods is challenging due to the extremely short lifetime of the myelin matrix ¹H MR signal, which significantly limits its observability. In this work, the fraction of total myelin matrix ¹H MR signal that is observable by an inversion-recovery (IR)-prepared zero echo-time (ZTE) imaging with pointwise encoding time reduction with radial acquisition (PETRA) sequence using various acquisition parameters is estimated by Bloch equation simulations. Only approximately 5% of total magnetization is observable under realistic experimental conditions. The adiabatic inversion-recovery pulse is mostly responsible for this low fractional observability.

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