Abstract #1826

Increased functional connectivity between medial prefrontal cortex and nucleus accumbens in morphine craving rats

Hannes Michel Wiesner¹, Shinho Cho¹, Yi Zhang¹, Erin Larson², Mark J. Thomas³, Xiao-Hong Zhu¹, and Wei Chen¹

¹CMRR, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, ²MnDRIVE Optogenetics and Neuromodulation Core, Neuroscience Department, University of Minnesota Medical School, Minneapolis, MN, United States, ³Departments of Neuroscience and Psychology, University of Minnesota Medical School, Minneapolis, MN, United States

Morphine is a potent analgesic with a high addictive potential. In this study we have shown a difference in brain connectivity related to drug-seeking behavior involving key neural decision and reward systems using rs-fMRI. The finding contributes to a better understanding of the neural underpinnings of opioid addiction and could help in a better assessment of relapse risk in individuals.

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