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Abstract #1818

MR Spectroscopic evaluation of brain white matter metabolite abnormalities in Psychotic Spectrum Disorders

Ines Blockx1, Matthew Lustberg1, Taylor C Coats1, Hillary C Bertisch2, Oded Gonen1,3, Donald C Goff4, and Mariana Lazar1

1Department of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2Department of Rehabilitation Medicine, New York University School of Medicine, New York, NY, United States, 3Department of Radiology, Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, 4Department of Psychiatry, New York University School of Medicine, New York, NY, United States

1H-MRS has been widely applied in studies with Psychotic Spectrum Disorders, however, findings are mixed and the exact cause of these disorders remains to be elucidated.The preliminary results of the present study show increased Gln/Cr levels in schizophrenia and schizoaffective patients in central WM reaching statistical significance in the bipolar group. The increase in Gln/Cr levels has been proposed to occur in the early stages of the disorder which is consistent with the population included here. The current study brings WM as a relevant area susceptible to damage into focus, which is likely to be involved in the early stages of PSD.

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