Abstract #1808

Amygdala dysfunction during negative emotional situation in Obsessive-Compulsive Disorder

Hyunsil Cha¹, Sang Won Lee², Kyung Eun Jang¹, Hyejeong Choi¹, Eunji Kim¹, Moojin Yang¹, Jiung Yang¹, Moon Jung Hwang³, Huijin Song⁴, Seung Jae Lee², and Yongmin Chang^1,5

¹Department of Medical & Biological Engineering, Kyungpook national university, Daegu, Republic of Korea, ²Department of Psychiatry, Kyungpook national university hospital, Daegu, Republic of Korea, ³GE Healthcare, Seoul, Republic of Korea, ⁴Biomedical Engineering Research, Kyungpook national university, Daegu, Republic of Korea, ⁵Department of Radiology and Molecular Medicine, Kyungpook national university, Daegu, Republic of Korea

We investigated brain activation in obsessive-compulsive disorder (OCD) patient using thought-action fusion (TAF) task to assess the influence of OCD symptom on amygdala response to the task. Within and between group analysis of close and neutral condition showed decreased amygdala activation in patients with OCD compared to healthy control.

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