Abstract #1784

Magnetization transfer ratio in cortical gray matter: a longitudinal study.

Yash P. Patel^1,2, Jean Shin^2,3, Penny A. Gowland⁴, and Tomas Paus^2,5,6,7

¹Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ²Rotman Research Institute, University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁴Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁵Center for Developing Brain, Child Mind Institute, New York, NY, United States, ⁶Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁷Department of Psychology, University of Toronto, Toronto, ON, Canada

To assess the change in magnetization transfer ratio (MTR) in the human cerebral cortex during adolescence(14 to 19 years of age). We observe an age-related increase in average MTR in both sexes. Inter-regional profiles of MTR measured at a single time-point correlate with gene-expression profiles of CA1 pyramidal cells (membranes of dendritic arbor) but not of oligodendrocytes (myelin). On the other hand, profiles of the MTR change (from 14 to 19 years) correlate with gene-expression profiles of oligodendrocytes, suggesting that the change may be sensitive to intra-cortical myelination.

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