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Abstract #1769

Changes in neonatal regional brain volume associated with preterm birth and perinatal factors

Bonnie Alexander1, Claire E Kelly1, Chris Adamson1, Richard Beare1,2, Diana Zannino1, Jian Chen1,2, Andrea Murray1, Wai Yen Loh1,3,4, Lillian G Matthews5, Simon K Warfield6, Peter J Anderson1,7,8, Lex W Doyle1,8,9,10, Marc Seal1,8, Alicia Spittle1,9,11, Jeanie Cheong1,9,10, and Deanne K Thompson1,3,8

1Murdoch Children's Research Institute, Melbourne, Australia, 2Dept of Medicine, Monash University, Melbourne, Australia, 3Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 4The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia, 5Dept of Newborn Medicine, Harvard Medical School, Boston, MA, United States, 6Dept of Radiology, Harvard Medical School, Boston, MA, United States, 7Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, 8Dept of Paediatrics, The University of Melbourne, Melbourne, Australia, 9Neonatal services, Royal Women's Hospital, Melbourne, Australia, 10Dept of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, 11Dept of Physiotherapy, The University of Melbourne, Melbourne, Australia

In a cohort of 285 preterm and term infants at term equivalent age, associations were investigated between gestational age (GA) at birth, perinatal factors, and volumes of 100 regions of the M-CRIB neonatal brain atlas. Volumes increased with increasing GA in some regions, and decreased with increasing GA in other regions including primary visual, motor and somatosensory cortices. Robust increases in many regional volumes were found for birthweight standard deviation score, and male sex. These results provide increased insight into the complex array of correlates of preterm birth.

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