Prostate diffusion EPI scans suffer from geometric distortions, signal pile-up and signal drop-out due to differences in susceptibility values at interface between prostate and rectal-air. In this work, an integrated model based framework is proposed that can correct for signal pile-up in regions of severe distortions and can compensate for any translational offsets that may exist between different scans. In-vivo validation of the proposed method is done in patients.
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