Abstract #1619

Evaluation of Monopolar Diffusion-Prepared TSE for Diffusion Imaging

Jialu Zhang^1,2,3, Xiufeng Li³, Kamil Ugurbil³, Anna Wang Roe^1,2, Xiaotong Zhang^1,2,4, and Dingxin Wang³

¹Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China, ²College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ³Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, ⁴Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China

EPI-based diffusion imaging methods are dominantly used, but suffer from susceptibility associated distortion and signal loss, making it challenging to achieve high-quality high-resolution diffusion imaging results. To overcome these challenges, we implemented monopolar diffusion preparation module for TSE sequence (DP-TSE) and evaluated the performance in comparison to readout segmented multi-shot echo planner (RESOLVE) sequence for diffusion weighted imaging (DWI). Our study results suggest that Diffusion-Prepared TSE is a promising alternative for distortion-free, high-resolution diffusion imaging with superior diffusion SNR.

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