The compartmentalized structure of biological tissues demands a representation of individual compartments and a description of diffusion within them. We identified a quadratic potential energy profile, recently studied in-depth by Yolcu et al. (Phys Rev E, 93, 052602, 2016), as the effective energy landscape for restricted diffusion as far as gradient waveforms featuring long pulses are concerned. Our simulations suggest that the stochastic effective force on the center-of-mass position is approximately linear, thus providing further support for the Hookean effective force model.
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