Abstract #1597

Are Intravoxel Incoherent Motion and Dynamic Contrast-Enhanced Perfusion Parameters Related in Glioblastomas?

Nicholas Majtenyi¹, Thanh B. Nguyen^2,3, Gerd Melkus², Ryan Gotfrit⁴, Gregory O. Cron^2,3,5, and Ian G. Cameron^1,2,3

¹Department of Physics, Carleton University, Ottawa, ON, Canada, ²Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, ³Radiology, University of Ottawa, Ottawa, ON, Canada, ⁴Department of Undergraduate Medical Education, University of Ottawa, Ottawa, ON, Canada, ⁵The Ottawa Hospital Research Institute, Ottawa, ON, Canada

Intravoxel incoherent motion (IVIM) is an MR-based diffusion-weighted imaging technique that can measure both diffusion and perfusion. Currently, no link has been established between the perfusion parameters obtained from IVIM to those from dynamic contrast-enhanced (DCE)-MRI, particularly in the human brain. This study determined that no correlation exists between these two perfusion measurement techniques in patients with glioblastomas. This indicates that these two imaging techniques measure two separate effects; however, IVIM may be able to provide complementary, additional perfusion information that can potentially aid clinical diagnoses when used in conjunction with DCE-MRI parameters.

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