Aim of this study was to develop a MRI-based radiomic method to assess lipomatous soft tissue tumors malignancy. 105 subjects with lipomatous soft tissue tumors whose histology was known and with fat-suppressed T1w contrast enhanced MR images available were retrospectively enrolled to constitute a database. Based on histology, three groups were constituted according to malignancy from lipomas to high grade liposarcomas. A decisional algorithm based on 2 multivariate radiomic models was built to distinguish between these groups. Results demonstrate that the evaluation of lipomatous tumor malignancy is feasible using a routinely used MRI acquisition in clinical practice.
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