Abstract #1496

Radiofrequency applicator concepts for RF hyperthermia treatment and MR imaging of glioblastoma multiforme at 7.0 T (298 MHz)

Eva Oberacker¹, Andre Kuehne², Helmar Waiczies², Jacek Nadobny³, Mirko Weihrauch³, Sebastian Zschaeck³, Pirus Ghadjar³, Peter Wust³, Thoralf Niendorf^1,2,4, and Lukas Winter¹

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²MRI.TOOLS GmbH, Berlin, Germany, ³Clinic for Radiation Oncology, Charite University Medicine, Berlin, Germany, ⁴Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Glioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no prognosis of long-term survival by the use of current multimodal therapeutic approaches. RF heating at ultrahigh fields (B₀=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on EMF simulations and compares RF applicator designs tailored for simultaneous RF heating and MRI. Our results suggest that RF power can be focused to small tumor areas and to large clinical target volumes derived from segmented patient data.

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