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Abstract #1479

Dependence of Focused-Ultrasound Induced Blood-Brain Barrier Opening Effect with Exposure Time: Evaluation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

Wen-Yen Chai1,2, Po-Chun Chun3, Sheng-Kai Wu4, Chih-Hung Tsai2, Hsin-Yi Lai5, and Hao-Li Liu2

1Department of Diagnostic Radiology and Intervention, Chang-Gung Memorial Hospital, Taoyuan, Taiwan, 2Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, 3Department of Research and Development, NaviFUS corp., Taipei, Taiwan, 4Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 5Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University, Hangzhou, China

FUS exposure with presence of microbubbles can transiently open the BBB at targeted brain tissues. The study purpose is to investigate the dependency of the BBB opening effect with ultrasound exposure time by DCE-MRI. Our result showed extending exposure time can effectively increase FUS-induced BBB opening degree without causing tissue damage. We also proposed a strategy by adjusting exposure time during the multiple exposures to overcome the effects that microbubbles concentration dynamic changed after IV bolus injection. This approach of control FUS exposure time may bring technology advances of FUS-induced BBB opening to deliver drug for CNS disease treatment.

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