Abstract #1377

Analysis of the Local Associations between Morphology and Biochemical Composition of the Articular Cartilage after Anterior Cruciate Ligament Injury and Reconstructive Surgery using Voxel-Based Relaxometry

Onyekachi Ezinna Nnabue^1,2, Hatef Mehrabian¹, Valentina Pedoia¹, Berk Norman¹, Benjamin C. Ma², and Sharmila Majumdar¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States

This study uncovered new insights on the local associations between cartilage thickness and T_1ρ relaxation time (a marker of cartilage proteoglycan content). Using Voxel-based relaxometry, this study quantified the longitudinal and cross-sectional thickness changes that occur in both the ACL-injured knee and the healthy contralateral in the lateral femoral condyle, medial femoral condyle, trochlea, medial tibia, lateral tibia, and patella and examined compartment-specific associations with relaxometry at various time points.

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