Abstract #1367

Does maternal swimming during gestation protects the neonatal brain from hypoxic-ischemic injury?

Yohan van de Looij^1,2,3, Eduardo Sanchez¹, Petra S Hüppi¹, and Stéphane V Sizonenko¹

¹Service développement et croissance, Université de Genève, Geneva, Switzerland, ²Laboratoire d'imagerie fonctionnelle et métabolique, Ecole polytechnique fédérale de Lausanne, Lausanne, Switzerland, ³Institut translationnel d'imagerie moléculaire, Université de Genève, Geneva, Switzerland

There are growing evidences that swimming during gestation has a neuroprotective effect on offspring perinatal brain injuries. The aim of this work was to assess this neuroprotective effect on P3 hypoxic-ischemic model by ¹H-MRS and diffusion MRI (DTI and NODDI) at 9.4T. A moderate, but real effect of swimming during gestation on the neurochemical profile 24h after HI was observed. Difference in neurochemical profile between sedentary and swimming rats may lead to a different response to the injury. At long-term, diffusion MRI derived parameters changes following HI were restored in the swimming HI group, providing evidence of a neuroprotective effect.

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