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Abstract #1359

Contribution of Intramyocellular Lipids to the Decrease in Muscle Density with Age

Nicholas A. Brennan1, Kenneth W. Fishbein1, David A. Reiter2, Richard G. Spencer1, and Luigi Ferrucci3

1Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States

Muscle density has been shown to decrease with age. However, the basis for this decrease remains unclear. We hypothesize that this decrease is associated with increased IMCL, and evaluated this relationship using localized 1H MRS of the vastus medialis muscle. We find that increased IMCL and decreased muscle density are strongly correlated across a large age range, even after controlling for multiple potential confounding variables.

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