Abstract #1357

Anterior cingulate cortex glutathione decreases with age - faster in women than in men?

Adriana Anton¹, Catherine Gregory¹, Richard Smallman¹, Silke Conen¹, Faezeh Sanaei-nezhad², Bill Deakin¹, and Steve Williams²

¹Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, ²Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom

The anti-oxidant glutathione (GSH) may protect against ageing. Significantly lower GSH in the occipital cortex has been reported in elderly compared to young healthy volunteers. Here we show that GSH is also decreased in middle-aged (N=8, 39-54y) compared to young (N=8, 22-32y) healthy subjects in the anterior cingulate but not the occipital cortex using GSH-edited MEGA-PRESS at 3T. This significant difference is driven by the women in the middle-age sub-group (significantly lower GSH than in men). This suggests that age-related oxidative stress begins earlier in women compared to men and sex composition of a studied group could influence results.

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