The utility of magnetic resonance spectroscopy for studying temporal lobe epilepsy (TLE) has been limited by magnetic field inhomogeneities. Using a 7T head-only MR system, we have successfully measured a number of metabolites which are challenging to measure in the hippocampus, including glutamate and glutathione, and we have observed a trend suggesting a decrease in creatine between contralateral and ipsilateral hippocampi in patients with unilateral, 1.5T MRI normal TLE.
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