We recently presented a method for extracting statistical descriptors of pH heterogeneity from lineshapes of pH-sensitive 31P MRS resonances. The first step in this analysis is the conversion of the resonance in question into the corresponding pH profile. The latter is then corrected for non-linearity between chemical shift and pH. However, this procedure is insufficient since the unequal spacing of the digital points making up such pH profiles needs to be compensated for by appropriate weighting. Exact statistical descriptor values are of importance in quantification of tissue pH heterogeneity, an issue that has received major attention in recent cancer research.
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