Abstract #1327

How does inclusion of different macromolecular baseline models affect reproducibility of 1H-FID MRSI in the brain at 7T?

Eva Heckova¹, Ursel Antpusat^1,2, Michal Považan^3,4, Bernhard Strasser⁵, Gilbert Hangel¹, Lukas Hingerl¹, Philipp Moser¹, Stephan Gruber¹, Siegfried Trattnig^1,6, and Wolfgang Bogner^1,6

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Hamm-Lippstadt University of Applied Sciences, Hamm, Germany, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁶Christian Doppler Laboratory for Clinical Molecular Molecular MR Imaging, Vienna, Austria

The goal was to investigate how the use of different macromolecular baseline models affects both the accuracy and test-retest reproducibility of metabolite quantification for clinically attractive FID-MRSI scan with in-plane resolution of 3.4 x 3.4 mm² and acquisition time of 5 min. We confirmed that our 1H-FID-MRSI sequence provides information about abundance and spatial distribution of several neurometabolites with high accuracy. Including the information about the macromolecular background into the quantification process does not decrease its reproducibility.

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