Abstract #1306

MOSAIC - a generalized multi-channel coil combination for 1H-MRSI via interleaved calibration scans

Philipp Moser^1,2, Bernhard Strasser³, Lukas Hingerl¹, Michal Považan^4,5, Gilbert Hangel¹, Eva Heckova¹, Stephan Gruber¹, Siegfried Trattnig^1,2, and Wolfgang Bogner¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

The optimal combination of signals from all receive elements is a prerequisite in MRSI especially at high field (≥7T), not only for SNR-efficient acquisition, but also for good parallel imaging reconstruction [1,2]. Phantom and in vivo experiments showed superior performance of MOSAIC including higher SNR, smaller FWHM and anatomically detailed metabolic maps compared to Brown and WSDV coil combination. MOSAIC is a flexible and robust approach for efficient MRSI coil combination under challenging conditions (B0≥7T, many coil elements, no reference coil, low SNR, possible spectral artifacts, motion/instability related artifacts, 1st-order phase error), especially with an outlook on parallel-imaging non-Cartesian MRSI.

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