Changes in lipid composition, such as polyunsaturated fatty acids (PUFA), have found to be potential biomarker of breast cancer. It has been shown that PUFA has a role in breast cancer initiation. The relationship in human between lipid composition and breast tumour grading warrants urgent investigation, as a pathway towards improved treatment. Conventional MRS suffers from overlap of nearby lipid and water peaks, and is insufficient for lipid composition measurement. We conducted double quantum filtered (DQF) correlation spectroscopy (COSY) to resolve lipid composition from the whole breast tumour, and multiple quantum coherence (MQC) MRS for further close investigation of PUFA.
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