While functional MRI (fMRI) localizes regions of activation, functional MRS (fMRS) provides metabolic response to activation. fMRS, using short echo-time (TE) non-edited 1H-MRS protocols, has been shown to be capable of detecting a lactate increase in sensory-induced activations. Because short TE non-edited lactate spectra are susceptible to functional hyperemia and contamination from lipids/macromolecules, we posited if long TE J-edited 1H-MRS detection of lactate can reliably detect metabolic changes in the motor cortex (MC) during the standard finger-tapping paradigm. Our fMRS results at 4T showed significant physiological modulation of the MC lactate level.
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