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Abstract #1271

Metabolite cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables 1H magnetic resonance spectroscopic imaging at 3 Tesla in a clinically feasible timeframe

Adam Steel1,2, Mark Chiew3, Peter Jezzard4, Natalie Voets4, Puneet Plaha4, M. Albert Thomas5, Charlotte J Stagg4, and Uzay E Emir6

1Nuffield Department of Medicine, University of Oxford, Headington, United Kingdom, 2National Institute of Mental Health, National Institutes of Health, Bethesda, DC, United States, 3Nuffield Department of Clinical Neuroscience, University of Oxford, Headington, United Kingdom, 4Nuffield Department of Clinical Neurosciences, University of Oxford, Headington, United Kingdom, 5Department of Radiology, University of California Los Angelas, Los Angeles, CA, United States, 6School of Health Sciences, Purdue University, West Lafayette, IN, United States

In this study, we demonstrate that a metabolite-cycled semi-LASER pulse localization with density-weighted concentric rings trajectory (DW-CRT) enables high-resolution MRSI to be acquired at 3 Tesla within a clinically feasible acquisition time. High-resolution (5 x 5 x 10 mm3) DW-CRT feasibility at 3T was assessed in 6 healthy volunteers. Subsequently, the clinical utility of this approach was demonstrated by mapping the presence of 2-HG in a patient with a grade III oligodendroglioma tumor.

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